Ti3C2Tx MXene-Au nanoparticles doped polyimide thin film as a transducing bioreceptor for real-time acoustic detection of carcinoembryonic antigen

Ti3C2Tx MXene was synthesized and the 2D layers were hybridized with Au nanoparticle (AuNP) through in-situ method. The study successfully prepared layer same TEM captured as well. Polyimide/MXene-AuNP (PI/Mxene-AuNP) transducing conducting nanocomposite thin film evaluated new material’s capability to use a for biosensing application. bioreceptor on delay line area of SAW device by covalently immobilizing mouse monoclonal antibody carcinoembryonic antigen (CEA) thioglycolic acid arm linker mechanism. Immunoassay analysis has suggested that biosensor responds linearly increase in concentration CEA sample. limit detection observed at 0.001 ng/mL. insertion loss recorded 10 dB, which also mattered high sensitivity biosensor. shown excellent selectivity within environment other common tumour markers stable 75 days under periodical testing conditions. Clinical serum samples analyzed results compared values obtained ELISA